PPM1D: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

PPM1D

Synonyms

IDDGIP | JDVS | PP2C-DELTA | WIP1

Gene Description

PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D, also known as wild-type p53-induced phosphatase 1 (Wip1), is a nuclear serine/threonine phosphatase that inhibits ATM, CHK2, p38MAPK and TP53 signaling (PMID: 32006900). PPM1D is often amplified in human cancers (PMID: 19879149), including breast cancer (PMID: 32006900), and overexpression is associated with poor prognosis in esophageal (PMID: 30374621) and gastric cancers (PMID: 32006900).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
8493	17	17q23.2	NM_003620	Oncogene (PMID: 30606230)

Additional content available in

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Gene Variants 102
Category Variants 13
Molecular Profiles 107
Evidence 53
Clinical Trials 1

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PPM1D - Gene Detail

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