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Gene Symbol CBFB
Synonyms CLCD2 | PEBP2B
Gene Description CBFB, core-binding factor beta subunit, is a transcription factor (PMID: 31061501) of the non DNA-binding regulatory subunit that complexes with Runx1, Runx2, or Runx3 proteins to make up the core-binding factors that are involved in regulating hematopoiesis (PMID: 15156179). CBFB is frequently involved in chromosomal translocations, such as CBFB-MYH11 (PMID: 31399807, PMID: 31721036) in leukemia (PMID: 8351518) and sarcoma (PMID: 31671434), and CBFB mutations have been observed in breast cancer (PMID: 31061501).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
865 16 16q22.1 NM_001755 Tumor suppressor (PMID: 30606230)
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