Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol STX11
Synonyms FHL4 | HLH4 | HPLH4
Gene Description STX11, syntaxin 11, is a member of the SNARE family that regulates lytic granules fusion in cytotoxic T-cells (PMID: 24227526) and degranulation of macrophages and NK cells (PMID: 21388490, PMID: 23042080). Germline STX11 mutations result in familial hemophagocytic lymphohistiocytosis type-4 (PMID: 15703195), and STX11 loss has been identified in peripheral T-cell lymphoma (PMID: 26176172).
Additional content available in CKB BOOST