ABCC3 - Gene Detail
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| Gene Symbol | ABCC3 | ||||||||||||
| Synonyms | ABC31 | cMOAT2 | EST90757 | MLP2 | MOAT-D | MRP3 | ||||||||||||
| Gene Description | ABCC3, ATP binding cassette subfamily C member 3, is an ATP-dependent efflux pump involved in transport of organic anions out of cells (PMID: 10359813, PMID: 16586096), including glucuronides (PMID: 17300812), toxins, and anionic drugs (PMID: 25380746), and may contribute to chemoresistance (PMID: 27171227, PMID: 26733163). Mutations in ABCC3 have been observed in breast and prostate cancer (PMID: 40641097) and overexpression of Abcc3 has been observed in pancreatic ductal adenocarcinoma (PMID: 31053501), bladder cancer (PMID: 26733163), and breast cancer (PMID: 27171227). | ||||||||||||
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