CD84 - Gene Detail
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| Gene Symbol | CD84 | ||||||||||||
| Synonyms | hCD84 | LY9B | mCD84 | SLAMF5 | ||||||||||||
| Gene Description | CD84, CD84 molecule, is a homophilic adhesion receptor that plays a role in stabilizing B-T cell interaction (PMID: 20153220), maintaining B-cell tolerance at the germinal center checkpoint (PMID: 25801429), promoting activation of T-cells (PMID: 12928397) and autophagy in dendritic cells (PMID: 29434592), and suppressing FceRI-mediated signaling in mast cells (PMID: 22068234), and may promote immunosuppression in the tumor microenvironment by inducing PD-L1 expression (PMID: 33465053, PMID: 30277471). CD84 overexpression has been observed in chronic lymphocytic leukemia (PMID: 23435417) and acute myeloid leukemia (PMID: 40633676, PMID: 42098093). | ||||||||||||
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