HERC2: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

HERC2

Synonyms

D15F37S1 | jdf2 | MRT38 | p528 | SHEP1

Gene Description

HERC2, HECT and RLD domain containing E3 ubiquitin protein ligase 2, is an E3 ubiquitin ligase involved in DNA damage response (PMID: 22508508, PMID: 25355518, PMID: 25305019), suppression of G-quadruplex formation (PMID: 30279242, PMID: 31582797), cell cycle progression through regulation of BRCA1 stability (PMID: 20631078), and DNA replication (PMID: 21775519). HERC2 mutations have been identified in skin cancers (PMID: 36883553), T-cell prolymphocytic leukemia (PMID: 29352181), and gastric and colorectal carcinoma (PMID: 22124266).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
8924	15	15q13.1	NM_004667	Unknown

Additional content available in

CKB BOOST

Gene Variants 2
Category Variants 0
Molecular Profiles 2
Evidence 0
Clinical Trials 0

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Gene Variants

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Global Drug Approvals

Drug Classes

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Clinical Trials

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Efficacy Evidence

Variant Tier Coding
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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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HERC2 - Gene Detail

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