AIP: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

AIP

Synonyms

ARA9 | FKBP16 | FKBP37 | PITA1 | SMTPHN | XAP-2 | XAP2

Gene Description

AIP, aryl hydrocarbon receptor interacting protein, is a chaperone protein involved in stabilization and localization of AhR (PMID: 38479600), and through its interaction with numerous binding partners plays a role in immune response (PMID: 25911105, PMID: 31042473), apoptosis (PMID: 34588620), cytoskeletal organization (PMID: 29507682), and proliferation (PMID: 18381572). Germline AIP mutations have been associated with pituitary adenomas (PMID: 38479600) and overexpression of Aip has been identified in diffuse large B-cell lymphoma (PMID: 31042473).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
9049	11	11q13.2	NM_003977	Unknown

Additional content available in

CKB BOOST

Gene Variants 2
Category Variants 0
Molecular Profiles 2
Evidence 0
Clinical Trials 0

KEY FEATURES

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Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

AIP - Gene Detail

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