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Gene Symbol MAP3K6
Synonyms ASK2 | MAPKKK6 | MEKK6
Gene Description MAP3K6, mitogen-activated protein kinase kinase kinase 6, is a member of the apoptosis signal-regulating kinase (ASK) family that regulates stress response (PMID: 17210579, PMID: 17714688) and apoptosis (PMID: 19214184). Germline MAP3K6 mutation is associated with gastric cancer (PMID: 25340522, PMID: 29330337), mutations in MAP3K6 have been observed in mixed-phenotype acute leukemia (PMID: 36232559), and decreased expression has been observed in esophageal squamous cell carcinoma (PMID: 19214184).
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