INA: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

INA

Synonyms

NEF5 | NF-66 | NF66 | TXBP-1

Gene Description

INA, internexin neuronal intermediate filament protein alpha, also known as alpha-internexin is a type IV intermediate filament protein of the cytoskeleton that may play a role in cell differentiation (PMID: 29940892). Altered expression of Ina has been reported in medulloblastomas, neuroblastomas, while loss of expression has been observed in gastroenteropancreatic neuroendocrine neoplasms (PMID: 29940892), and an FGFR2-INA fusion has been reported in low-grade mixed neuronal-glial tumors (PMID: 29767381) and intrahepatic cholangiocarcinoma (PMID: 31109923).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
9118	10	10q24.33	NM_032727	Unknown

Additional content available in

CKB BOOST

Gene Variants 6
Category Variants 2
Molecular Profiles 5
Evidence 9
Clinical Trials 0

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Genes

(50 Genes)

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Gene Variants

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Global Drug Approvals

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Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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INA - Gene Detail

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