PTTG1: Gene Detail - Cancer Knowledgebase (CKB)

To all our CKB CORE users, don’t miss the latest new features now available! Register for a free CORE account here and then login for access. Feel free to contact us at ckbsupport@genomenon.com if you have any questions!

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol

PTTG1

Synonyms

EAP1 | ECRAR | HPTTG | PTTG | TUTR1

Gene Description

PTTG1, securin, is also known as pituitary tumor transforming gene-1 and plays a role in chromosome stability (PMID: 10411507), angiogenesis through Fgf2, and signal transduction downstream of Src kinase (PMID: 27766744). Overexpression of Pttg1 has been observed in several tumor types, including laryngeal cancer (PMID: 30061937), meningioma (PMID: 29575197), NSCLC (PMID: 27829547), pituitary tumors (PMID: 9092795), and ovarian carcinoma, where it may promote tumor progression and metastasis (PMID: 27766744).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
9232	5	5q33.3	NM_004219	Unknown

Additional content available in

CKB BOOST

Gene Variants 2
Category Variants 0
Molecular Profiles 2
Evidence 1
Clinical Trials 1

KEY FEATURES

CKB CORE^TM

CKB BOOST^TM

CKB FLEX^TM

Access 50 genes & related content

Access 2000+ genes & related content

Scalable & flexible content integration for 2000+ genes

Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

PTTG1 - Gene Detail

Contact