ATG5: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

ATG5

Synonyms

Gene Description

ATG5, autophagy related 5, is a component of autophagy, which regulates formation of the autophagosome (PMID: 36062813) and plays a role in various cellular processes including immune response (PMID: 20171125, PMID: 18996346), B-cell development (PMID: 18188005), and cellular differentiation (PMID: 19844159, PMID: 25227738). ATG5 mutations have been identified in gastrointestinal cancers (PMID: 19197948) and decreased expression of Atg5 has been observed in colorectal cancer (PMID: 22993366).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
9474	6	6q21	NM_004849	Unknown

Additional content available in

CKB BOOST

Gene Variants 3
Category Variants 1
Molecular Profiles 3
Evidence 0
Clinical Trials 0

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Gene Variants

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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ATG5 - Gene Detail

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