CTR9: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

CTR9

Synonyms

p150 | p150TSP | SH2BP1 | TSBP

Gene Description

CTR9, CTR9 homolog, Paf1/RNA polymerase II complex component, encodes a transcriptional regulator of the PAF1 complex that associates with RNA polymerase II during transcription (PMID: 20060942, PMID: 11884586, PMID: 30228257, PMID: 39244754), and plays a role in epigenetic regulation and embryonic development (PMID: 24036311). CTR9 mutations have been identified in myeloid malignancies (PMID: 38218188) and germline CTR9 mutations have been associated with predisposition to Wilm's tumor (PMID: 25099282, PMID: 29292210, PMID: 39293508).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
9646	11	11p15.4	NM_014633	Unknown

Additional content available in

CKB BOOST

Gene Variants 2
Category Variants 0
Molecular Profiles 2
Evidence 0
Clinical Trials 0

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Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

CTR9 - Gene Detail

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