CROCC: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

CROCC

Synonyms

CROCC1 | ROLT | TAX1BP2

Gene Description

CROCC, ciliary rootlet coiled-coil, rootletin, encodes a protein involved in ciliogenesis (PMID: 33596093) and centrosome cohesion (PMID: 32325071, PMID: 36285440) and also functions as an effector of ATM in mediating DNA damage response (PMID: 24240686). CROCC inactivating mutations are associated with rhabdoid colorectal carcinoma (PMID: 29784668, PMID: 30852641, PMID: 37239344), decreased expression has been observed in hepatocellular carcinoma (PMID: 22610972), and an FGFR2-CROCC fusion has been identified in cholangiocarcinoma (PMID: 38710951).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
9696	1	1p36.13	NM_014675	Unknown

Additional content available in

CKB BOOST

Gene Variants 4
Category Variants 3
Molecular Profiles 3
Evidence 1
Clinical Trials 0

KEY FEATURES

CKB CORE^TM

CKB BOOST^TM

CKB FLEX^TM

Access 50 genes & related content

Access 2000+ genes & related content

Scalable & flexible content integration for 2000+ genes

Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

CROCC - Gene Detail

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