Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol KEAP1
Synonyms INrf2 | KLHL19
Gene Description KEAP1, kelch like ECH associated protein 1, binds Nrf2 and targets it for ubiquitin-mediated degradation, thereby negatively regulating the downstream cytoprotective activity of Nrf2 (PMID: 24142871, PMID: 27263465, PMID: 28523248). KEAP1 loss-of-function mutations have been identified in several tumor types, including lung and liver cancers (PMID: 24142871, PMID: 27263465, PMID: 29615460).
Additional content available in CKB BOOST