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KEAP1 - Gene Detail

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Gene Symbol KEAP1
Synonyms INrf2 | KLHL19
Gene Description KEAP1, kelch like ECH associated protein 1, binds Nrf2 and targets it for ubiquitin-mediated degradation, thereby negatively regulating the downstream cytoprotective activity of Nrf2 (PMID: 24142871, PMID: 27263465, PMID: 28523248). KEAP1 loss-of-function mutations have been identified in several tumor types, including lung and liver cancers (PMID: 24142871, PMID: 27263465, PMID: 29615460).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
9817 19 19p13.2 NM_203500 Tumor suppressor (PMID: 30606230)

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Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries