PALB2 D219G
Gene Variant Detail

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Gene PALB2
Variant D219G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PALB2 D219G lies within the DNA-binding and BRCA1-interacting regions of the Palb2 protein (UniProt.org). D219G has been identified in sequencing studies (PMID: 23935836, PMID: 20122277, PMID: 26283626), but has not been biochemically characterized and therefore, its effect on Palb2 protein function is unknown (PubMed, May 2026).
Associated Drug Resistance
Category Variants Paths

PALB2 mutant PALB2 D219G

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Transcript NM_024675.4
gDNA chr16:g.23635890T>C
cDNA c.656A>G
Protein p.D219G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017023672 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
XM_017023673 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
XM_017023672.2 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
XM_017023673.2 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
NM_001407297.1 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
NM_001407301.1 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
NM_024675 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
NM_024675.4 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
NM_001407302.1 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
NM_001407298.1 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
NM_001407299.1 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
NM_024675.3 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38
NM_001407300.1 chr16:g.23635890T>C c.656A>G p.D219G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References