SRC T341I
Gene Variant Detail

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Gene SRC
Variant T341I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions SRC T341I lies within the protein kinase domain of the Src protein (UniProt.org). T341I results in increased Src autophosphorylation, substrate phosphorylation, and cell survival in culture (PMID: 18794843, PMID: 29930727) and demonstrates resistance to Src inhibition in cell culture (PMID: 29930727, PMID: 19098899).
Associated Drug Resistance Y
Category Variants Paths

SRC mutant SRC act mut SRC T341I

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Transcript NM_198291.3
gDNA chr20:g.37400277_37400278delCGinsTC
cDNA c.1022_1023delCGinsTC
Protein p.T341I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047440402.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_047440403.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
NM_005417.4 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
NM_005417 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_011529013.2 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_047440401.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_047440406.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
NM_005417.5 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
NM_198291.3 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_047440413.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_047440412.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
NM_198291 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_047440411.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_047440405.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_011529013 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_047440404.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
XM_047440410.1 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
NM_198291.2 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References