MSH6 F1088Lfs*5
Gene Variant Detail

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Gene MSH6
Variant F1088Lfs*5
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions MSH6 F1088Lfs*5 indicates a shift in the reading frame starting at amino acid 1088 and terminating 5 residues downstream causing a premature truncation of the 1360 amino acid Msh6 protein (UniProt.org). F1088Lfs*5 has been identified in the scientific literature (PMID: 30877237, PMID: 30387329, PMID: 36091175), but has not been biochemically characterized and therefore, its effect on Msh6 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 F1088fs MSH6 F1088Lfs*5

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Transcript NM_000179.3
gDNA chr2:g.47803510_47803511insA
cDNA c.3263_3264insA
Protein p.F1088Lfs*5
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000179.2 chr2:g.47803510_47803511insA c.3263_3264insA p.F1088Lfs*5 RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47803510_47803511insA c.3263_3264insA p.F1088Lfs*5 RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47803510_47803511insA c.3263_3264insA p.F1088Lfs*5 RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47803510_47803511insA c.3263_3264insA p.F1088Lfs*5 RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47803510_47803511insA c.3263_3264insA p.F1088Lfs*5 RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47803510_47803511insA c.3263_3264insA p.F1088Lfs*5 RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47803510_47803511insA c.3263_3264insA p.F1088Lfs*5 RefSeq GRCh38/hg38
NM_000179 chr2:g.47803507_47803508insG c.3260_3261insG p.F1088Lfs*5 RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References