FLT3 L576R
Gene Variant Detail

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Gene FLT3
Variant L576R
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 L576R lies within the cytoplasmic domain of the Flt3 protein (UniProt.org). L576R results in increased phosphorylation of Flt3 and Stat5 in culture (EHA, June 2017, abstr P184).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 L576R

FLT3 mutant FLT3 exon14 FLT3 L576R

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Transcript NM_004119.3
gDNA chr13:g.28034192A>C
cDNA c.1727T>G
Protein p.L576R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28034192A>C c.1727T>G p.L576R RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28034192A>C c.1727T>G p.L576R RefSeq GRCh38/hg38
NM_004119 chr13:g.28034192A>C c.1727T>G p.L576R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References