FGFR1 P277L
Gene Variant Detail

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Gene FGFR1
Variant P277L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 P277L (corresponds to P366L in the canonical isoform) lies within Ig-like C2-type domain 3 of the Fgfr1 protein (UniProt.org). P277L has been identified in sequencing studies (PMID: 30503610), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 P277L

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Transcript NM_023105.3
gDNA chr8:g.38419720G>A
cDNA c.830C>T
Protein p.P277L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001174064.1 chr8:g.38424591G>A c.830C>T p.P277L RefSeq GRCh38/hg38
NM_001174066.2 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
NM_001174064 chr8:g.38424591G>A c.830C>T p.P277L RefSeq GRCh38/hg38
NM_023105.2 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
NM_001174066 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
NM_023105 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716309 chr8:g.38424591G>A c.830C>T p.P277L RefSeq GRCh38/hg38
NM_023105.3 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716310.4 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716311.1 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716311 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716310.3 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716311.1 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716310 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716312.2 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38424591G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38424591G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716312 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_006716312.2 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
XM_047421573.1 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
NM_001174066.1 chr8:g.38419720G>A c.830C>T p.P277L RefSeq GRCh38/hg38
NM_001174064.2 chr8:g.38424591G>A c.830C>T p.P277L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References