PALB2 T734S
Gene Variant Detail

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Gene PALB2
Variant T734S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PALB2 T734S does not lie within any known functional domains of the Palb2 protein (UniProt.org). T734S does not demonstrate reduced homology-directed DNA repair activity compared to wild-type Palb2 in cultured cells lacking Tp53 (PMID: 31636395), but has not been fully biochemically characterized and therefore, its effect on Palb2 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PALB2 mutant PALB2 T734S

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Transcript NM_024675.4
gDNA chr16:g.23629953G>C
cDNA c.2201C>G
Protein p.T734S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407306.1 chr16:g.23621389G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407302.1 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407300.1 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
XM_017023673.2 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407309.1 chr16:g.23621389G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
XM_017023673 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407308.1 chr16:g.23621389G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407304.1 chr16:g.23621389G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407297.1 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407299.1 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
XM_011545948.2 chr16:g.23621389G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407301.1 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_024675.4 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407296.1 chr16:g.23629893G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_024675.3 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407305.1 chr16:g.23621389G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407310.1 chr16:g.23621389G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
XM_017023672 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
XM_017023672.2 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407298.1 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_001407311.1 chr16:g.23621389G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
NM_024675 chr16:g.23629953G>C c.2201C>G p.T734S RefSeq GRCh38/hg38
XM_011545948 chr16:g.23621389G>C c.2201C>G p.T734S RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References