HRAS E143K
Gene Variant Detail

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Gene HRAS
Variant E143K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS E143K does not lie within any known functional domains of the Hras protein (UniProt.org). E143K has been identified in sequencing studies (PMID: 30462564, PMID: 29106415), but has not been biochemically characterized and therefore, its effect on Hras protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS E143K

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Transcript NM_005343.4
gDNA chr11:g.533476C>T
cDNA c.427G>A
Protein p.E143K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.5 chr11:g.533476C>T c.427G>A p.E143K RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533476C>T c.427G>A p.E143K RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533476C>T c.427G>A p.E143K RefSeq GRCh38/hg38
NM_005343 chr11:g.533476C>T c.427G>A p.E143K RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533476C>T c.427G>A p.E143K RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533476C>T c.427G>A p.E143K RefSeq GRCh38/hg38
NM_001130442 chr11:g.533476C>T c.427G>A p.E143K RefSeq GRCh38/hg38
NM_176795 chr11:g.533476C>T c.427G>A p.E143K RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533476C>T c.427G>A p.E143K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References