TP53 C176R
Gene Variant Detail

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Gene TP53
Variant C176R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 C176R lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). C176R has been identified in the scientific literature (PMID: 33250737, PMID: 37379264), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 C176R

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Transcript NM_000546.6
gDNA chr17:g.7675086A>G
cDNA c.526T>C
Protein p.C176R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407270.1 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675086A>G c.526T>C p.C176R RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References