PIK3CA L10_M16del
Gene Variant Detail

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Gene PIK3CA
Variant L10_M16del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA L10_M16del results in the deletion of seven amino acids of the Pik3ca protein from amino acids 10 to 16 (UniProt.org). L10_M16del has been identified in the scientific literature (PMID: 28528867, PMID: 23708221), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA L10_M16del

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Transcript NM_006218.4
gDNA chr3:g.179198854_179198874del21
cDNA c.29_49del21
Protein p.L10_M16delLWGIHLM
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179198854_179198874del21 c.29_49del21 p.L10_M16del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179198854_179198874del21 c.29_49del21 p.L10_M16delLWGIHLM RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179198854_179198874del21 c.29_49del21 p.L10_M16del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179198854_179198874del21 c.29_49del21 p.L10_M16delLWGIHLM RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179198854_179198874del21 c.29_49del21 p.L10_M16del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References