FGFR2 Q621L
Gene Variant Detail

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Gene FGFR2
Variant Q621L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 Q621L (corresponds to Q620L in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). Q621L has been identified in sequencing studies (PMID: 39706336), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 Q621L

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Transcript NM_022970.4
gDNA chr10:g.121496536T>A
cDNA c.1862A>T
Protein p.Q621L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.4 chr10:g.121496536T>A c.1862A>T p.Q621L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496536T>A c.1862A>T p.Q621L RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References