FGFR1 R470C
Gene Variant Detail

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Gene FGFR1
Variant R470C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 R470C lies within the cytoplasmic domain of the Fgfr1 protein (UniProt.org). R470C does not significantly alter serum dependency for growth in cell culture (PMID: 40526877), but has not been fully biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 R470C

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Transcript NM_023110.3
gDNA chr8:g.38418250G>A
cDNA c.1408C>T
Protein p.R470C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023110.3 chr8:g.38418250G>A c.1408C>T p.R470C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References