FLT3 T227M
Gene Variant Detail

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Gene FLT3
Variant T227M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 T227M lies within the extracellular domain of the Flt3 protein (UniProt.org). T227M has been identified in the scientific literature (PMID: 36739272, PMID: 29519565, PMID: 27534895), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 T227M

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Transcript NM_004119.3
gDNA chr13:g.28050157G>A
cDNA c.680C>T
Protein p.T227M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017020489.1 chr13:g.28035515G>A c.680C>T p.T227M RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28050157G>A c.680C>T p.T227M RefSeq GRCh38/hg38
XM_011535015 chr13:g.28050099_28050100delTGinsCA c.680_681delCAinsTG p.T227M RefSeq GRCh38/hg38
XM_017020486.2 chr13:g.28050157G>A c.680C>T p.T227M RefSeq GRCh38/hg38
XM_017020486 chr13:g.28050157G>A c.680C>T p.T227M RefSeq GRCh38/hg38
XM_017020486.1 chr13:g.28050157G>A c.680C>T p.T227M RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28050099_28050100delCAinsTG c.680_681delCAinsTG p.T227M RefSeq GRCh38/hg38
XM_011535015.3 chr13:g.28050099_28050100delCAinsTG c.680_681delCAinsTG p.T227M RefSeq GRCh38/hg38
XM_017020489 chr13:g.28035515G>A c.680C>T p.T227M RefSeq GRCh38/hg38
NM_004119 chr13:g.28050157G>A c.680C>T p.T227M RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28050157G>A c.680C>T p.T227M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References