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Gene STK11
Variant K78I
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions STK11 K78I lies within the protein kinase domain of the Stk11 protein (UniProt.org). K78I confers a loss of function to the Stk11 protein, as demonstrated by loss of kinase activity in cell culture (PMID: 15731909, PMID: 9837816), and an in vitro assay (PMID: 34849607), and decreased Tp53-mediated transcriptional activity in a reporter assay (PMID: 34849607), and is considered a kinase-dead mutation (PMID: 26864623).
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 K78I

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Transcript NM_000455.5
gDNA chr19:g.1207146_1207147delAGinsTC
cDNA c.233_234delAGinsTC
Protein p.K78I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.5 chr19:g.1207146_1207147delAGinsTC c.233_234delAGinsTC p.K78I RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1207146_1207147delAGinsTC c.233_234delAGinsTC p.K78I RefSeq GRCh38/hg38
NM_000455 chr19:g.1207146_1207147delAGinsTC c.233_234delAGinsTC p.K78I RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1207146_1207147delAGinsTC c.233_234delAGinsTC p.K78I RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1207146_1207147delAGinsTC c.233_234delAGinsTC p.K78I RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1207146_1207147delAGinsTC c.233_234delAGinsTC p.K78I RefSeq GRCh38/hg38
XM_005259617 chr19:g.1207146_1207147delAGinsTC c.233_234delAGinsTC p.K78I RefSeq GRCh38/hg38
XM_005259618 chr19:g.1207146_1207147delAGinsTC c.233_234delAGinsTC p.K78I RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References