Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene ROS1
Variant G1971E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 G1971E lies within the protein kinase domain of the Ros1 protein (UniProt.org). G1971E has been demonstrated to confer resistance to ROS1 tyrosine kinase inhibitors in the context of a ROS1 fusion in culture (PMID: 24218589), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 G1971E

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_002944.3
gDNA chr6:g.117319896C>T
cDNA c.5912G>A
Protein p.G1971E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117319896C>T c.5912G>A p.G1971E RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117319896C>T c.5912G>A p.G1971E RefSeq GRCh38/hg38
XM_011536050.3 chr6:g.117319923C>T c.5912G>A p.G1971E RefSeq GRCh38/hg38
XM_011536050 chr6:g.117319923C>T c.5912G>A p.G1971E RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117318238_117318239delGTinsAG c.5912_5913delGTinsAG p.G1971E RefSeq GRCh38/hg38
NM_002944 chr6:g.117319896C>T c.5912G>A p.G1971E RefSeq GRCh38/hg38
XM_017011173 chr6:g.117318238_117318239delACinsCT c.5912_5913delGTinsAG p.G1971E RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117318238_117318239delGTinsAG c.5912_5913delGTinsAG p.G1971E RefSeq GRCh38/hg38
XM_011536050.2 chr6:g.117319923C>T c.5912G>A p.G1971E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References