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Gene ROS1
Variant C2060G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 C2060G lies within the protein kinase domain of the Ros1 protein (UniProt.org). C2060G has been demonstrated to confer resistance to Ros1 tyrosine kinase inhibitors in the context of Ros1 fusion in culture (PMID: 24218589), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 C2060G

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Transcript NM_002944.3
gDNA chr6:g.117311075A>C
cDNA c.6178T>G
Protein p.C2060G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.3 chr6:g.117311075A>C c.6178T>G p.C2060G RefSeq GRCh38/hg38
NM_002944 chr6:g.117311075A>C c.6178T>G p.C2060G RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117311075A>C c.6178T>G p.C2060G RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References