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Gene | ARID1B |
Variant | dec exp |
Impact List | none |
Protein Effect | no effect |
Gene Variant Descriptions | ARID1B dec exp indicates decreased expression of the Arid1b protein. However, the mechanism causing the decreased expression is unspecified. |
Associated Drug Resistance | |
Category Variants Paths |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1B dec exp | Advanced Solid Tumor | predicted - sensitive | Cisplatin | Preclinical - Cell culture | Emerging | In a preclinical study, siRNA knockdown of ARID1B in cultured tumor cells resulted in increased sensitivity to Platinol (cisplatin), suggesting that tumors with ARID1B loss or inactivation may have increased response to DNA damaging agents (PMID: 24788099). | 24788099 |