JAK2 I540T
Gene Variant Detail

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Gene JAK2
Variant I540T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions JAK2 I540T does not lie within any known functional domains of the Jak2 protein (UniProt.org). I540T has been identified in the scientific literature (PMID: 21497288, PMID: 37834019), but has not been biochemically characterized and therefore, its effect on Jak2 protein function is unknown (PubMed, Feb 2025).
Associated Drug Resistance
Category Variants Paths

JAK2 mutant JAK2 exon12 JAK2 I540T

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Transcript NM_004972.4
gDNA chr9:g.5070030T>C
cDNA c.1619T>C
Protein p.I540T
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.