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Gene DNMT3A
Variant N879A
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions DNMT3A N879A lies within the dimer interface region of the Dnmt3a protein (PMID: 22722925). N879A disrupts the teramerization ability of the Dnmt3a protein, resulting in reduced DNA binding affinity, reduced methylation activity, and altered catalytic activity (PMID: 22722925).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A inact mut DNMT3A N879A

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Transcript NM_022552.5
gDNA chr2:g.25234382_25234383delAAinsGC
cDNA c.2635_2636delAAinsGC
Protein p.N879A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_175629 chr2:g.25234382_25234383delTTinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
NM_022552 chr2:g.25234382_25234383delTTinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25234382_25234383delAAinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
XM_017003526 chr2:g.25234382_25234383delTTinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25234382_25234383delAAinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
XM_005264175 chr2:g.25234382_25234383delTTinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25234382_25234383delAAinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25234382_25234383delAAinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25234382_25234383delAAinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25234382_25234383delAAinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25234382_25234383delAAinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25234382_25234383delAAinsGC c.2635_2636delAAinsGC p.N879A RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References