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Gene MSH6
Variant D422G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 D422G lies within an MSH2-binding region of the Msh6 protein (PMID: 12019211). D422G has not been characterized in the scientific literature and therefore, its effect on Msh6 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 D422G

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Transcript NM_000179.3
gDNA chr2:g.47799248A>G
cDNA c.1265A>G
Protein p.D422G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406796.1 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_001406802.1 chr2:g.47799152A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_001406817.1 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_001406803.1 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_001407362.1 chr2:g.47803567A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_001406798.1 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_001406795.1 chr2:g.47799152A>G c.1265A>G p.D422G RefSeq GRCh38/hg38
NM_000179 chr2:g.47799248A>G c.1265A>G p.D422G RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References