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Gene MSH6
Variant G93E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 G93E lies within the PWWP domain of the Msh6 protein (UniProt.org). G93E has been identified in sequencing studies (PMID: 29245953), but has not been biochemically characterized and therefore, its effect on Msh6 protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 G93E

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Transcript NM_000179.3
gDNA chr2:g.47790944G>A
cDNA c.278G>A
Protein p.G93E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406803.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_001407362.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_001406798.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_000179 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_001406817.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_001406813.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47790944G>A c.278G>A p.G93E RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References