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Gene MSH6
Variant I1183K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 I1183K lies within the ATPase domain of the Msh6 protein (PMID: 17531815). I1183K has not been characterized in the scientific literature and therefore, its effect on Msh6 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 I1183K

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Transcript NM_000179.3
gDNA chr2:g.47805019T>A
cDNA c.3548T>A
Protein p.I1183K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000179.3 chr2:g.47805019T>A c.3548T>A p.I1183K RefSeq GRCh38/hg38
NM_001281492 chr2:g.47806588_47806589delTTinsAG c.3548_3549delTTinsAG p.I1183K RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47805019T>A c.3548T>A p.I1183K RefSeq GRCh38/hg38
NM_001281492.2 chr2:g.47806588_47806589delTTinsAG c.3548_3549delTTinsAG p.I1183K RefSeq GRCh38/hg38
NM_000179 chr2:g.47805019T>A c.3548T>A p.I1183K RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47805019T>A c.3548T>A p.I1183K RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47805019T>A c.3548T>A p.I1183K RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47805019T>A c.3548T>A p.I1183K RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47805019T>A c.3548T>A p.I1183K RefSeq GRCh38/hg38
NM_001406826.1 chr2:g.47806273T>A c.3548T>A p.I1183K RefSeq GRCh38/hg38
NM_001281492.1 chr2:g.47806588_47806589delTTinsAG c.3548_3549delTTinsAG p.I1183K RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47805019T>A c.3548T>A p.I1183K RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References