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Gene MSH6
Variant R961I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 R961I lies within the clamp domain of the Msh6 protein (PMID: 17531815). R961I has been identified in sequencing studies (PMID: 22895193, PMID: 31391288), but has not been biochemically characterized and therefore, its effect on Msh6 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 R961I

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Transcript NM_000179.3
gDNA chr2:g.47800865G>T
cDNA c.2882G>T
Protein p.R961I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406809.1 chr2:g.47800865G>T c.2882G>T p.R961I RefSeq GRCh38/hg38
NM_001406829.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
XM_024452822.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001406815.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001281493.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47800865G>T c.2882G>T p.R961I RefSeq GRCh38/hg38
NM_000179 chr2:g.47800865G>T c.2882G>T p.R961I RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47800865G>T c.2882G>T p.R961I RefSeq GRCh38/hg38
NM_001281494.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001406798.1 chr2:g.47800865G>T c.2882G>T p.R961I RefSeq GRCh38/hg38
NM_001281494 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47800865G>T c.2882G>T p.R961I RefSeq GRCh38/hg38
NM_001406811.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001406813.1 chr2:g.47800858_47800859delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001406823.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001406816.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001281494.2 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001281493 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47800865G>T c.2882G>T p.R961I RefSeq GRCh38/hg38
NM_001281493.2 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001406812.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001406814.1 chr2:g.47806344_47806345delCGinsAT c.2881_2882delCGinsAT p.R961I RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47800865G>T c.2882G>T p.R961I RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47800865G>T c.2882G>T p.R961I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References