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Gene TP53
Variant R158G
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 R158G lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). R158G retains activation of Cdkn1a and results in DNA-binding similar to wild-type Tp53 in culture (PMID: 32350249) but leads to the loss of DNA-binding activity in an in vitro assay, interferes with transactivation by wild-type Tp73 in yeast (PMID: 9472631, PMID: 12917626), and results in reduced Pmaip1 transcription, increased motility and anchorage-independent cell growth in culture and increased tumor growth in a mouse model (PMID: 32350249), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 R158G

TP53 mutant TP53 inact mut TP53 R158G

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Transcript NM_000546.6
gDNA chr17:g.7675140G>C
cDNA c.472C>G
Protein p.R158G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126115.1 chr17:g.7673752G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126116 chr17:g.7673752G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126117.1 chr17:g.7673752G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_000546 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7673752G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126115 chr17:g.7673752G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126117.2 chr17:g.7673752G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126116.1 chr17:g.7673752G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126116.2 chr17:g.7673752G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675140G>C c.472C>G p.R158G RefSeq GRCh38/hg38
NM_001126117 chr17:g.7673752G>C c.472C>G p.R158G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 R158G lung non-small cell carcinoma sensitive Gedatolisib Preclinical Actionable In a preclinical study, Gedatolisib (PKI-587) inhibited growth of human non-small cell lung carcinoma cells harboring TP53 R158G in culture (PMID: 21325073, PMID: 23980093). 21325073 23980093