NRAS G12X
Gene Variant Detail

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Gene NRAS
Variant G12X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NRAS G12X indicates any NRAS missense mutation that results in replacement of the glycine (G) at amino acid 12 by a different amino acid. NRAS G12 mutations are hotspot mutations that often result in a loss of Nras GTPase activity and activation of downstream pathways (PMID: 27664710, PMID: 28666118, PMID: 22589270, PMID: 26985062).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon2 NRAS G12X

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Transcript NM_002524.5
gDNA chr1:g.114716125_114716127
cDNA c.34_36
Protein p.G12
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114716125_114716127 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716125_114716127 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_002524 chr1:g.114716125_114716127 c.34_36 p.G12 RefSeq GRCh38/hg38

Filtering

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Molecular Profile Protein Effect Treatment Approaches
NRAS G12X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)