NRAS G13X
Gene Variant Detail

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Gene NRAS
Variant G13X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NRAS G13X indicates any NRAS missense mutation that results in replacement of the glycine (G) at amino acid 13 by a different amino acid. NRAS G13 mutations are hotspot mutations that often result in decreased Nras GTPase activity and transformation of cultured cells (PMID: 17517660, PMID: 26985062).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon2 NRAS G13X

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Transcript NM_002524.5
gDNA chr1:g.114716122_114716124
cDNA c.37_39
Protein p.G13
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114716122_114716124 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_002524 chr1:g.114716122_114716124 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716122_114716124 c.37_39 p.G13 RefSeq GRCh38/hg38

Filtering

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Molecular Profile Protein Effect Treatment Approaches
NRAS G13X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)