NRAS Q61X
Gene Variant Detail

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Gene NRAS
Variant Q61X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NRAS Q61X indicates any NRAS missense mutation that results in replacement of the glutamine (Q) at amino acid 61 by a different amino acid. NRAS Q61 mutations are hotspot mutations that often result in a loss of Nras GTPase activity and activation of downstream pathways (PMID: 27664710, PMID: 28666118, PMID: 22589270, PMID: 26985062).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon3 NRAS Q61X

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Transcript NM_002524.5
gDNA chr1:g.114713907_114713909
cDNA c.181_183
Protein p.Q61
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713907_114713909 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713907_114713909 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713907_114713909 c.181_183 p.Q61 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
NRAS Q61X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)