Gene Variant Detail

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Gene STK11
Variant P281fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 P281fs likely results in a premature truncation of the Stk11 protein at amino acid 281 of 433 (UniProt.org). STK11 P281fs has not been characterized however, due to the effects of other truncation mutations downstream of P281 (PMID: 23612973), is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 P281fs

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Transcript NM_000455.5
gDNA chr19:g.(1221318_1221319)
cDNA c.(841_840)
Protein p.P281fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.5 chr19:g.(1221318_1221319) c.(841_840) p.P281fs RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.(1221318_1221319) c.(841_840) p.P281fs RefSeq GRCh38/hg38
XM_005259617 chr19:g.1221320delC c.842delC p.P281fs*6 RefSeq GRCh38/hg38
NM_000455.4 chr19:g.(1221318_1221319) c.(841_840) p.P281fs RefSeq GRCh38/hg38
XM_005259618 chr19:g.1221320delC c.842delC p.P281fs*6 RefSeq GRCh38/hg38
NM_000455 chr19:g.1221320delC c.842delC p.P281fs*6 RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.(1221318_1221319) c.(841_840) p.P281fs RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.(1221318_1221319) c.(841_840) p.P281fs RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries