Gene Variant Detail

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Gene STK11
Variant G61Afs*3
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 G61Afs*3 indicates a shift in the reading frame starting at amino acid 61 and terminating 3 residues downstream causing a premature truncation of the 433 amino acid Stk11 protein (UniProt.org). G61Afs*3 has not been characterized however, due to the effects of other truncation mutations downstream of G61 (PMID: 23612973), is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 G61Afs*3

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Transcript NM_000455.5
gDNA chr19:g.1207095delG
cDNA c.182delG
Protein p.G61Afs*3
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407255.1 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38
NM_000455 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38
XM_005259617 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38
XM_005259618 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38
XM_011528209 chr19:g.1219352_1219353insCCCCGTA c.181_182insCCCCGTA p.G61Afs*3 RefSeq GRCh38/hg38
XM_011528209.2 chr19:g.1219352_1219353insCCCCATA c.181_182insCCCCATA p.G61Afs*3 RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References