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Gene STK11
Variant L285Q
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 L285Q lies within the protein kinase domain of the Stk11 protein (UniProt.org). L285Q results in failure to activate the downstream kinase Ampk in an in vitro assay (PMID: 19892943), and therefore, is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 L285Q

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Transcript NM_000455.5
gDNA chr19:g.1221332T>A
cDNA c.854T>A
Protein p.L285Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.5 chr19:g.1221332T>A c.854T>A p.L285Q RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1221332T>A c.854T>A p.L285Q RefSeq GRCh38/hg38
XM_005259617 chr19:g.1221332T>A c.854T>A p.L285Q RefSeq GRCh38/hg38
NM_000455 chr19:g.1221332T>A c.854T>A p.L285Q RefSeq GRCh38/hg38
XM_005259618 chr19:g.1221332T>A c.854T>A p.L285Q RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1221332T>A c.854T>A p.L285Q RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1221332T>A c.854T>A p.L285Q RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1221332T>A c.854T>A p.L285Q RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References