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Gene STK11
Variant Q37*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 Q37* results in a premature truncation of the Stk11 protein at amino acid 37 of 433 (UniProt.org). Q37* has not been characterized however, due to the effects of other truncation mutations downstream of Q37 (PMID: 23612973), is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 Q37*

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Transcript NM_000455.5
gDNA chr19:g.1207022C>T
cDNA c.109C>T
Protein p.Q37*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259618 chr19:g.1207022C>T c.109C>T p.Q37* RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1207022C>T c.109C>T p.Q37* RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1207022C>T c.109C>T p.Q37* RefSeq GRCh38/hg38
XM_005259617 chr19:g.1207022C>T c.109C>T p.Q37* RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1207022C>T c.109C>T p.Q37* RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1207022C>T c.109C>T p.Q37* RefSeq GRCh38/hg38
NM_000455 chr19:g.1207022C>T c.109C>T p.Q37* RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1207022C>T c.109C>T p.Q37* RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
STK11 Q37* lung non-small cell carcinoma sensitive Trametinib Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung cancer cell lines harboring STK11 inactivating mutations, such as STK11 Q37*, demonstrated increased sensitivity to Mekinist (trametinib) in culture (PMID: 27821489). 27821489