STK11 G171S
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene STK11
Variant G171S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions STK11 G171S lies within the protein kinase domain of the Stk11 protein (UniProt.org). G171S fails to activate the downstream kinase Ampk in cell culture (PMID: 19892943), but results in kinase activity comparable to wild-type Stk11 in an in vitro assay (PMID: 10676634), and therefore, its effect on Stk11 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 G171S

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000455.5
gDNA chr19:g.1220419G>A
cDNA c.511G>A
Protein p.G171S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.1220419G>A c.511G>A p.G171S RefSeq GRCh38/hg38
XM_005259618 chr19:g.1220419G>A c.511G>A p.G171S RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1220419G>A c.511G>A p.G171S RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1220419G>A c.511G>A p.G171S RefSeq GRCh38/hg38
NM_000455 chr19:g.1220419G>A c.511G>A p.G171S RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1220419G>A c.511G>A p.G171S RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1220419G>A c.511G>A p.G171S RefSeq GRCh38/hg38
XM_005259617 chr19:g.1220419G>A c.511G>A p.G171S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
STK11 G171S unknown mTOR Inhibitor mTORC1 Inhibitor