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Gene STK11
Variant I177N
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions STK11 I177N lies within the protein kinase domain of the Stk11 protein (UniProt.org). I177N confers a loss of function to the Stk11 protein, as demonstrated by its inability to activate the downstream kinase, Ampk (PMID: 19892943), lack of autophosphorylation, loss of cytoplasmic localization, and the inability to suppress growth of cells in culture (PMID: 12552571).
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 I177N

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Transcript NM_000455.5
gDNA chr19:g.1220438T>A
cDNA c.530T>A
Protein p.I177N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.1220438T>A c.530T>A p.I177N RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1220438T>A c.530T>A p.I177N RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1220438T>A c.530T>A p.I177N RefSeq GRCh38/hg38
XM_005259618 chr19:g.1220438T>A c.530T>A p.I177N RefSeq GRCh38/hg38
XM_005259617 chr19:g.1220438T>A c.530T>A p.I177N RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1220438T>A c.530T>A p.I177N RefSeq GRCh38/hg38
NM_000455 chr19:g.1220438T>A c.530T>A p.I177N RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1220438T>A c.530T>A p.I177N RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References