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Gene STK11
Variant N181E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions STK11 N181E lies within the protein kinase domain of the Stk11 protein (UniProt.org). N181E results in failure to activate the downstream kinase Ampk in an vitro assay (PMID: 19892943) and demonstrates reduced association with the Strad-Mo25 complex (PMID: 26212320).
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 N181E

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Transcript NM_000455.5
gDNA chr19:g.1220449_1220451delAACinsGAG
cDNA c.541_543delAACinsGAG
Protein p.N181E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259618.3 chr19:g.1220449_1220451delAACinsGAG c.541_543delAACinsGAG p.N181E RefSeq GRCh38/hg38
NM_000455 chr19:g.1220449_1220451delAACinsGAG c.541_543delAACinsGAG p.N181E RefSeq GRCh38/hg38
XM_005259617 chr19:g.1220449_1220451delAACinsGAG c.541_543delAACinsGAG p.N181E RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1220449_1220451delAACinsGAG c.541_543delAACinsGAG p.N181E RefSeq GRCh38/hg38
XM_005259618 chr19:g.1220449_1220451delAACinsGAG c.541_543delAACinsGAG p.N181E RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1220449_1220451delAACinsGAG c.541_543delAACinsGAG p.N181E RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1220449_1220451delAACinsGAG c.541_543delAACinsGAG p.N181E RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1220449_1220451delAACinsGAG c.541_543delAACinsGAG p.N181E RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References