Gene Variant Detail

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Gene STK11
Variant E199K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions STK11 E199K lies within the protein kinase domain of the Stk11 protein (UniProt.org). E199K fails to activate the downstream kinase Ampk in cell culture (PMID: 19892943), but results in kinase activity comparable to wild-type Stk11 in an in vitro assay (PMID: 10676634), and therefore, its effect on Stk11 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 E199K

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Transcript NM_000455.5
gDNA chr19:g.1220503G>A
cDNA c.595G>A
Protein p.E199K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407255.1 chr19:g.1220503G>A c.595G>A p.E199K RefSeq GRCh38/hg38
XM_005259617 chr19:g.1220503G>A c.595G>A p.E199K RefSeq GRCh38/hg38
NM_000455 chr19:g.1220503G>A c.595G>A p.E199K RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1220503G>A c.595G>A p.E199K RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1220503G>A c.595G>A p.E199K RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1220503G>A c.595G>A p.E199K RefSeq GRCh38/hg38
XM_005259618 chr19:g.1220503G>A c.595G>A p.E199K RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1220503G>A c.595G>A p.E199K RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References