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| Gene | ERBB3 |
| Variant | act mut |
| Impact List | unknown |
| Protein Effect | gain of function |
| Gene Variant Descriptions | ERBB3 (HER3) act mut indicates that this variant results in a gain of function in the Erbb3 (Her3) protein. However, the specific amino acid change has not been identified. |
| Associated Drug Resistance | |
| Category Variants Paths |
ERBB3 mutant ERBB3 act mut |
| Molecular Profile | Protein Effect | Treatment Approaches |
|---|---|---|
| ERBB3 act mut | gain of function | HER inhibitor (Pan) HER2 Inhibitor HER3 Inhibitor Pertuzumab Trastuzumab |