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Gene | TP53 |
Variant | T377S |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 T377S lies within the region of the Tp53 protein involved in repression of DNA binding and the CARM1-interacting region (UniProt.org). T377S has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Nov 2024). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon11 TP53 T377S |
Transcript | NM_000546.6 |
gDNA | chr17:g.7669661G>C |
cDNA | c.1130C>G |
Protein | p.T377S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000546.5 | chr17:g.7669661G>C | c.1130C>G | p.T377S | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7669661G>C | c.1130C>G | p.T377S | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7669661G>C | c.1130C>G | p.T377S | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7669661G>C | c.1130C>G | p.T377S | RefSeq | GRCh38/hg38 |
NM_001126112 | chr17:g.7669661G>C | c.1130C>G | p.T377S | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7669661G>C | c.1130C>G | p.T377S | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7669661G>C | c.1130C>G | p.T377S | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7669661G>C | c.1130C>G | p.T377S | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7669661G>C | c.1130C>G | p.T377S | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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